Figure 2 – Timing chart — from Perspectives on Auditory Neuropathy: Disorders of Inner Hair Cell, Auditory Nerve, and Their Synapse

23 Dec 2014

Figure 2 from Perspectives on Auditory Neuropathy: Disorders of Inner Hair Cell, Auditory Nerve, and Their Synapse:7 A representation of the patterns of activity of afferent auditory nerve fibers with synaptic connections to an inner hair cell. The onset of a transient stimulus is indicated by the vertical line below. The occurrence of fiber activity in a normally functioning system is represented by black arrows while fiber activity in an abnormal system is represented by gray arrows. The patterns of activity in the two conditions are shown below. The abnormalities of fiber activity that are represented include (a) variable delay in the latency of discharge and (b) absence of a response in 30%of the fibers. Note the short latency and synchrony of the population’s response when the system is normal and the delayed latency, temporal dispersion, and reduced amplitude of the population’s response when the system is abnormal. We suggest that the pattern of abnormality of activity would be similar whether the disorder were at inner hair cell, the synapse including neurotransmitter release, reuptake and binding to receptor sites, or in the nerve fibers. However, the extent of latency delay and variability as well as in the proportion of fibers that are activated would vary according to the type and extent of the pathological processes.

About the author

Dan Schwartz

Electrical Engineer, via Georgia Tech

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